JK-273
Modify Date: 2024-01-15 14:07:40
JK-273 structure
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Common Name | JK-273 | ||
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| CAS Number | 187723-38-2 | Molecular Weight | 335.790 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H14ClN5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JK-273A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis. |
| Name | 6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine |
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| Synonym | More Synonyms |
| Description | A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin; inhibits α4 integrin signaling, shows a selective cytotoxic effect against HCI-H460 NSCLC cells with IC50 of 0.98 uM, less sensitivity to fibroblasts (30-fold selectivity), causes cell cycle arrest at S phase and induces apoptosis. |
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| References | References 1. Lee J, et al. Bioorg Med Chem. 2009 Feb 1;17(3):977-80. 2. Lu TN, et al. Biochem Biophys Res Commun. 2017 Sep 16;491(2):355-360. View Related Products by Target Integrin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H14ClN5 |
| Molecular Weight | 335.790 |
| Exact Mass | 335.093781 |
| LogP | 4.70 |
| Index of Refraction | 1.777 |
| 6-(4-Aminophenyl)-N-(3-chlorophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine |
| 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-(4-aminophenyl)-N-(3-chlorophenyl)- |