WAY 181187 oxalate
Modify Date: 2024-01-19 11:54:14
WAY 181187 oxalate structure
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Common Name | WAY 181187 oxalate | ||
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| CAS Number | 1883548-85-3 | Molecular Weight | 470.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H13ClN4O2S2.C2H2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of WAY 181187 oxalateWAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2]. |
| Name | WAY 181187 oxalate |
|---|---|
| Synonym | More Synonyms |
| Description | WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2]. |
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| Related Catalog | |
| Target |
5-HT6 Receptor:2.2 nM (Ki) 5-HT6 Receptor:6.6 nM (EC50) |
| In Vitro | WAY-181187 (SAX-187) oxalate (1 and 10 μM) increases activation of ERK1/2. WAY181187 also increases Fyn kinase activity[2]. |
| In Vivo | Acute administration of WAY-181187 (SAX-187) oxalate (3-30 mg/kg, s.c.) significantly increases extracellular GABA concentrations without altering the levels of glutamate or norepinephrine in the rat frontal cortex. Additionally, WAY-181187 oxalate (30 mg/kg, s.c.) produces modest yet significant decreases in cortical dopamine and 5-HT levels[1]. |
| References |
| Molecular Formula | C15H13ClN4O2S2.C2H2O4 |
|---|---|
| Molecular Weight | 470.91 |
| Exact Mass | 470.012146 |
| 1H-Indole-3-ethanamine, 1-[(6-chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-, ethanedioate (1:1) |
| WAY-181187 OXALATE |
| 1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate |
| 2-{1-[(6-Chloroimidazo[2,1-b][1,3]thiazol-5-yl)sulfonyl]-1H-indol-3-yl}ethanamine ethanedioate (1:1) |