LE-540

Modify Date: 2024-02-02 21:37:14

LE-540 Structure
LE-540 structure
Common Name LE-540
CAS Number 188645-44-5 Molecular Weight 488.631
Density N/A Boiling Point N/A
Molecular Formula C33H32N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LE-540


A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.

 Names

Name LE-540

 LE-540 Biological Activity

Description A potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements; inhibits ATRA-induced apoptosis in ZR-75-1 human breast cancer cells; strongly represses 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity in the presence of RARβ and RARα.
References References 1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6. 2. Kitaoka K, et al. Brain Res. 2011 Nov 14;1423:10-6. 3. Umemiya H, et al. J Med Chem. 1997 Dec 19;40(26):4222-34. View Related Products by Target RAR/RXR

 Chemical & Physical Properties

Molecular Formula C33H32N2O2
Molecular Weight 488.631
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