BIBO 3304 trifluoroacetate
Modify Date: 2025-08-27 17:26:27
BIBO 3304 trifluoroacetate structure
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Common Name | BIBO 3304 trifluoroacetate | ||
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| CAS Number | 191868-14-1 | Molecular Weight | 643.65700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H36F3N7O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BIBO 3304 trifluoroacetateBIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively)[1]. |
| Name | BIBO 3304 trifluoroacetate,N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamideditrifluoroacetate |
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| Synonym | More Synonyms |
| Description | BIBO3304 TFA is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively)[1]. |
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| Related Catalog | |
| In Vivo | BIBO3304 TFA (30 μg; bilateral paraventricular nucleus injection) attenuates the hyperphagia following fasting[1]. BIBO3304 TFA (15-60 μg) dose-dependently inhibits the feeding reponse mediated by 1 μg NPY[1]. BIBO3304 TFA (0.5 μM; p.o.) significantly increases serum insulin levels[2]. Animal Model: Adult male Chbb:Thom rats weighing between 300 and 340 g[1] Dosage: 30 μg Administration: bilateral paraventricular nucleus injection Result: Attenuated the hyperphagia following fasting, especially during the first 2 h of refeeding. Animal Model: 7-week-old C57BL/6JAusb mice[2] Dosage: 0.5 μM Administration: p.o. Result: Significantly increased serum insulin levels. |
| References |
| Molecular Formula | C31H36F3N7O5 |
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| Molecular Weight | 643.65700 |
| Exact Mass | 643.27300 |
| PSA | 212.52000 |
| LogP | 5.74850 |
| InChIKey | FBMCYYWIBYEOST-GJFSDDNBSA-N |
| SMILES | NC(=O)NCc1ccc(CNC(=O)C(CCCN=C(N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1.O=C(O)C(F)(F)F |
| Storage condition | 2-8°C |
| hi topk 032 |