Iclaprim

Modify Date: 2024-01-06 12:18:37

Iclaprim Structure
Iclaprim structure
Common Name Iclaprim
CAS Number 192314-93-5 Molecular Weight 354.403
Density 1.3±0.1 g/cm3 Boiling Point 616.7±65.0 °C at 760 mmHg
Molecular Formula C19H22N4O3 Melting Point N/A
MSDS N/A Flash Point 326.8±34.3 °C

 Use of Iclaprim


Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 mg/mL.

 Names

Name iclaprim
Synonym More Synonyms

 Iclaprim Biological Activity

Description Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 mg/mL.
Related Catalog
Target

Dihydrofolate[1]

References

[1]. Schneider P, et al. Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4217-21.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 616.7±65.0 °C at 760 mmHg
Molecular Formula C19H22N4O3
Molecular Weight 354.403
Flash Point 326.8±34.3 °C
Exact Mass 354.169189
PSA 105.51000
LogP 2.20
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.666
Storage condition 2-8℃

 Synonyms

Iclaprim
2,4-Pyrimidinediamine, 5-[(2-cyclopropyl-7,8-dimethoxy-2H-1-benzopyran-5-yl)methyl]-
5-[(2-cyclopropyl-7,8-dimethoxy-2h-chromen-5-yl)methyl]pyrimidine-2,4-diamine
5-[(2-Cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)methyl]-2,4-pyrimidinediamine