MDR-652

Modify Date: 2025-08-25 14:02:15

MDR-652 Structure
MDR-652 structure
Common Name MDR-652
CAS Number 1933528-96-1 Molecular Weight 447.95
Density N/A Boiling Point N/A
Molecular Formula C22H23ClFN3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MDR-652


MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The Kis are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC50s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity[1].

 Names

Name MDR-652

 MDR-652 Biological Activity

Description MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The Kis are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC50s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity[1].
Related Catalog
Target

hTRPV1:11.4 nM (Ki)

rTRPV1:23.8 nM (Ki)

hTRPV1:5.05 nM (EC50)

rTRPV1:93 nM (EC50)

In Vivo MDR-652 (0.5 and 5 mg/kg) displays a dose-dependent decrease of body temperature, supporting that MDR-652 displays TRPV1 agonism in the intact animal[1]. MDR-652 (5-10 mg/kg; i.p. and s.c.) blocks the neuropathic pain completely, indicating 100% maximum possible effect (MPE) [1]. MDR-652 has a promising topical pharmacokinetic profile[1]. MDR-652 has no significant toxicity. In a single-dose toxicity study, the LD50 of MDR-652 is higher than 200 and 2000 mg/kg in i.p. and p.o. administration, respectively[1]. Animal Model: ICR mouse[1] Dosage: 0.5 and 5 mg/kg Administration: Administered intraperitoneally; 7 hours Result: Decreased body temperature in a dose-dependent manner. Animal Model: Rats with spinal nerve ligation (SNL) model[1] Dosage: 1, 2, 5, and 10 mg/kg Administration: Administered intraperitoneally and subcutaneously; 24 hours Result: The i.p. administration exhibited an excellent and dose dependent analgesic profile with an ED50 of 0.5-2 mg/kg. The subcutaneous injection (sc) also displayed an excellent analgesic outcome with maximum effect at 30 min after administration.
References

[1]. Jihyae Ann, et al. Discovery of Nonpungent Transient Receptor Potential Vanilloid 1 (TRPV1) Agonist as Strong Topical Analgesic. J Med Chem. 2020 Jan 9;63(1):418-424.

 Chemical & Physical Properties

Molecular Formula C22H23ClFN3O2S
Molecular Weight 447.95
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here



Get all suppliers and price by the below link:

MDR-652 suppliers


Price: ¥3000/5 mg

Reference only. check more MDR-652 price

Related Compounds: More...
(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-[[4-[[[(2S,3S,4S,6R)-6-[[(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy]-3-hydroxy-2-methyloxan-4-yl]amino]methyl]phenyl]methylamino]-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-tri
186131-38-4
Chromate(3-), bis[2-[[6-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-1-hydroxy-3-sulfo-2-naphthalenyl]azo]benzoato(3-)]-, sodium
93820-71-4
palamoll(r) 652
208945-13-5
sodium bis[N-[4-[4,5-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-3-methyl-5-oxo-1H-pyrazol-1-yl]phenyl]acrylamidato(2-)]chromate(1-)
80997-94-0
DYPROSIUM SELENIDE
12020-04-1
uk 65662
120832-02-2
Alkanes, C2-3
68475-58-1
Lanolin, sodium salt
70528-78-8
Chlorophyllins, copper potassium sodium
1337-20-8
1-(4-Chloro-phenyl)-5-trifluoromethyl-1h-pyrazole-4-carboxylic acid [5-chloro-2-(1h-tetrazol-5-yl)-phenyl]-amide
1083418-31-8
4-Phenylisoxazole-3-carboxylic acid
1524204-66-7
3,4-Dihydro-2H-pyrrolehydrochloride
85236-75-5
3-[(N-[1-pyrrolin-2-yl]anilino)methyl]-1-methylindole
51596-86-2
4-(Chlorosulfonyl)thiophene-3-carboxylic acid
1375472-54-0
(R)-2-allyl-5-methylcyclohex-2-en-1-one
90528-94-2
1-(4-Bromo-benzyl)-5-methyl-1h-[1,2,3]triazole-4-carboxylic acid [5-chloro-2-(1h-tetrazol-5-yl)-phenyl]-amide
1083418-33-0
4-Chloro-2-{[5-(4-chloro-phenyl)-2-trifluoromethyl-furan-3-carbonyl]-amino}-benzene-sulfonic acid
1083418-39-6
5-(4-Chloro-phenyl)-2-trifluoromethyl-furan-3-carboxylic acid [5-chloro-2-(1h-tetrazol-5-ylmethoxy)-phenyl]-amide
1083418-41-0
4,5-Dichloro-2-{[5-(4-chloro-phenyl)-2-trifluoromethyl-furan-3-carbonyl]-amino}-benzenesulfonic acid
1083418-43-2