alamifovir

Modify Date: 2024-01-10 08:05:50

alamifovir Structure
alamifovir structure
 Common Name alamifovir
CAS Number 193681-12-8 Molecular Weight 575.42200
Density 1.61g/cm3 Boiling Point 635.9ºC at 760mmHg
Molecular Formula C19H20F6N5O5PS Melting Point N/A
MSDS N/A Flash Point 338.4ºC

 Use of alamifovir


Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].

 Names

Name alamifovir
Synonym More Synonyms

 alamifovir Biological Activity

Description Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].
Related Catalog
In Vitro MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM，对 M552I 为 2.6 μM，对 M552V 为 3.3 μM，对 L528M/M552V 为 2.0 μM[ 1]。
References

[1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5.  

[2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8.  

 Chemical & Physical Properties

Density 1.61g/cm3
Boiling Point 635.9ºC at 760mmHg
Molecular Formula C19H20F6N5O5PS
Molecular Weight 575.42200
Flash Point 338.4ºC
Exact Mass 575.08300
PSA 158.72000
LogP 5.47450
Vapour Pressure 4.51E-16mmHg at 25°C
Index of Refraction 1.582

 Synthetic Route

4-Methoxythiophenol structure

4-Methoxythiophenol

CAS#:696-63-9

Bis(2,2,2-trifluoroethyl) {[2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy]methyl}phosphonate structure

Bis(2,2,2-trifl...

CAS#:186345-42-6

~68%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Sekiya, Kouichi; Takashima, Hideaki; Ueda, Naoko; Kamiya, Naohiro; Yuasa, Satoshi; Fujimura, Yoshiyuki; Ubasawa, Masaru Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3138 - 3142
bis(2,2,2-trifluoroethyl) [(2-chloroethoxy)methyl]phosphonate structure

bis(2,2,2-trifl...

CAS#:186345-40-4

~%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556
1,1,1-trifluoro-2-[2-iodoethoxymethyl(2,2,2-trifluoroethoxy)phosphoryl]oxyethane structure

1,1,1-trifluoro...

CAS#:186345-41-5

~%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556
4-Mercaptophenol structure

4-Mercaptophenol

CAS#:637-89-8

~%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556
Bis(2,2,2-trifluoroethyl) {[2-(2-amino-6-chloro-9H-purin-9-yl)ethoxy]methyl}phosphonate structure

Bis(2,2,2-trifl...

CAS#:186345-42-6

~%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556
4-Methoxythiophenol structure

4-Methoxythiophenol

CAS#:696-63-9

~%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556
Guanine structure

Guanine

CAS#:73-40-5

~%

alamifovir Structure

alamifovir

CAS#:193681-12-8

Literature: Wang, Ji-Quan; Fei, Xiangshu; Gardner, Thomas A.; Hutchins, Gary D.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 549 - 556

 Synonyms

mcc 478
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