alamifovir

Modify Date: 2024-01-10 08:05:50

alamifovir structure	Common Name	alamifovir
	CAS Number	193681-12-8	Molecular Weight	575.42200
	Density	1.61g/cm3	Boiling Point	635.9ºC at 760mmHg
	Molecular Formula	C₁₉H₂₀F₆N₅O₅PS	Melting Point	N/A
	MSDS	N/A	Flash Point	338.4ºC

Use of alamifovir

Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].

Name	alamifovir
Synonym	More Synonyms

Description	Alamifovir (LY582563; MCC-478), a purine nucleotide analogue prodrug, shows potent activity against wild type and lamivudine resistant hepatitis B virus (HBV). Alamifovir has high activity against HBV replication and sustained antiviral effect[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	MCC-478 (0-10 μM) 对野生型 HBV 的 EC50 为 0.027 μM，对 M552I 为 2.6 μM，对 M552V 为 3.3 μM，对 L528M/M552V 为 2.0 μM[ 1]。
References	[1]. Suzane Kioko Ono-Nita, et al. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002 Aug;46(8):2602-5. [2]. Danny K W Soon, et al. Safety and efficacy of alamifovir in patients with chronic hepatitis B virus infection. J Hepatol. 2004 Nov;41(5):852-8.

Density	1.61g/cm3
Boiling Point	635.9ºC at 760mmHg
Molecular Formula	C₁₉H₂₀F₆N₅O₅PS
Molecular Weight	575.42200
Flash Point	338.4ºC
Exact Mass	575.08300
PSA	158.72000
LogP	5.47450
Vapour Pressure	4.51E-16mmHg at 25°C
Index of Refraction	1.582

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alamifovir

CAS#:193681-12-8

Literature: Sekiya, Kouichi; Takashima, Hideaki; Ueda, Naoko; Kamiya, Naohiro; Yuasa, Satoshi; Fujimura, Yoshiyuki; Ubasawa, Masaru Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3138 - 3142