YKL-1-116
Modify Date: 2024-06-08 16:38:55
YKL-1-116 structure
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Common Name | YKL-1-116 | ||
|---|---|---|---|---|
| CAS Number | 1957202-71-9 | Molecular Weight | 606.731 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H38N8O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YKL-1-116YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant). |
| Name | YKL-1-116 |
|---|
| Description | YKL-1-116 is a potent, selective and covalent inhibitor of CDK7 that does not inhibit other CDKs; synergizes with 5-FU or nutlin-3 to kill HCT116 cells, produces dose-dependent increases in PARP cleavage; is more potent than THZ1 towards both Cdk7WT and Cdk7as (analog-sensitive mutant). |
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| References | References 1. Kalan S, et al. Cell Rep. 2017 Oct 10;21(2):467-481. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Molecular Formula | C34H38N8O3 |
|---|---|
| Molecular Weight | 606.731 |