Picromycin

Modify Date: 2026-06-30 15:17:44

Picromycin Structure
Picromycin structure
 Common Name Picromycin
CAS Number 19721-56-3 Molecular Weight 525.67
Density 1.14g/cm3 Boiling Point 688.1ºC at 760mmHg
Molecular Formula C28H47NO8 Melting Point N/A
MSDS N/A Flash Point 369.9ºC

 Use of Picromycin


Pikromycin is a macrolide antibiotic that has been found in S. venezuelae and active against E. coli, S. aureus and B. subtilis[1].

Summary: Pikromycin (Chinese name: 吡罗霉素, CAS number: 19721-56-3) is a 14-membered macrolide antibiotic and inhibitor of Prolyl endopeptidase (PREP), with a molecular formula of C28H47NO8 and a molecular weight of 525.67. It exhibits significant antibacterial activity against Gram-positive bacteria including mycobacteria. For research-use only, not for medical or clinical usage.

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name pikromycin
Synonym More Synonyms

 Picromycin Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Pikromycin is a macrolide antibiotic that has been found in S. venezuelae and active against E. coli, S. aureus and B. subtilis[1].
Related Catalog
References

[1]. Gupta S, et al. Generation of novel pikromycin antibiotic products through mutasynthesis. Chembiochem. 2008 Jul 2;9(10):1609-16.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.14g/cm3
Boiling Point 688.1ºC at 760mmHg
Molecular Formula C28H47NO8
Molecular Weight 525.67
Flash Point 369.9ºC
Exact Mass 525.33000
PSA 122.60000
LogP 2.51290
Vapour Pressure 6.51E-22mmHg at 25°C
Index of Refraction 1.521
InChIKey UZQBOFAUUTZOQE-VSLWXVDYSA-N
SMILES CCC1OC(=O)C(C)C(=O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)CC(C)C(=O)C=CC1(C)O

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TJ8225000
CHEMICAL NAME :
Picromycin
CAS REGISTRY NUMBER :
19721-56-3
LAST UPDATED :
199510
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C28-H47-N-O8
MOLECULAR WEIGHT :
525.76
WISWESSER LINE NOTATION :
T-12-OV HV IUTJ C1 E1 G1 KQ K1 L2 FO- BT6OTJ CQ DN1&1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,287,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
249 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,114,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
508 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 1,101,1978

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Albomycetin
picromycin
Pikromycin
Amaromycin

 Picromycin | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of pikromycin?
A: CAS number of pikromycin is 19721-56-3.
Q: What is the English name of pikromycin?
A: The English name of pikromycin is pikromycin.
Q: What is the SMILES notation of pikromycin?
A: SMILES notation of pikromycin is CCC1OC(=O)C(C)C(=O)C(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)CC(C)C(=O)C=CC1(C)O.
Q: What is the LogP of pikromycin?
A: LogP of pikromycin is 2.51290.
Q: What are the uses of pikromycin?
A: Main uses of pikromycin: Pikromycin is a macrolide antibiotic that has been found in S. venezuelae and active against E. coli, S. aureus and B. subtilis[1].
Q: What is the molecular weight of pikromycin?
A: Molecular weight of pikromycin is 525.67.
Q: What is the boiling point of pikromycin?
A: Boiling point of pikromycin is 688.1ºC at 760mmHg.
Q: What is the molecular formula of pikromycin?
A: Molecular formula of pikromycin is C28H47NO8.
Q: What is the InChIKey of pikromycin?
A: InChIKey of pikromycin is UZQBOFAUUTZOQE-VSLWXVDYSA-N.
Q: What is the polar surface area (PSA) of pikromycin?
A: Polar surface area (PSA) of pikromycin is 122.60000.

 Picromycinfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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Chemsrc provides Picromycin(CAS#:19721-56-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Picromycin are included as well.>> amp version: Picromycin

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