(Z)-JIB-04

Modify Date: 2026-07-16 17:35:17

(Z)-JIB-04 Structure
(Z)-JIB-04 structure
Common Name (Z)-JIB-04
CAS Number 199596-24-2 Molecular Weight 308.765
Density 1.2±0.1 g/cm3 Boiling Point 472.9±55.0 °C at 760 mmHg
Molecular Formula C17H13ClN4 Melting Point N/A
MSDS N/A Flash Point 239.8±31.5 °C

 Use of (Z)-JIB-04


(Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis[1].

 Names

Name 5-Chloro-2-{(2Z)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine
Synonym More Synonyms

 (Z)-JIB-04 Biological Activity

Description (Z)-JIB-04 (NSC693627) is the Z isomer of JIB-04 that has two forms, E (HY-13953) and Z isomers. (Z)-JIB-04 is inactive in epigenetic analysis[1].
Related Catalog
In Vitro JIB-04 inhibits the demethylase activity of Jumonji enzymes in vitro and in cells, without affecting other α-ketoglutarate dependent hydroxylases or histone modifying enzymes [1].
References

[1]. Wang L, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 472.9±55.0 °C at 760 mmHg
Molecular Formula C17H13ClN4
Molecular Weight 308.765
Flash Point 239.8±31.5 °C
Exact Mass 308.082886
LogP 3.92
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.644
InChIKey YHHFKWKMXWRVTJ-XLNRJJMWSA-N
SMILES Clc1ccc(NN=C(c2ccccc2)c2ccccn2)nc1
Storage condition -20℃

 (Z)-JIB-04Bioassay

View more

Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose
Name: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell...
Source: DTP/NCI
Target: N/A
External Id: IGROV1_OneDose
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 Synonyms

5-Chloro-2-{(2Z)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine
Z-JIB-04
NSC 693627
JIB-04 (NSC 693627)-Z
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