Nacubactam
Modify Date: 2025-08-26 00:25:46
Nacubactam structure
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Common Name | Nacubactam | ||
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| CAS Number | 2007923-17-1 | Molecular Weight | 342.326 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H18N4O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NacubactamNacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo. Bacterial Infection Phase 1 Clinical |
| Name | (2S,5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide hydrate (1:1) |
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| Synonym | More Synonyms |
| Description | Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial; exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp; increases the antibacterial activity of cefepime in both in vitro and in vivo. Bacterial Infection Phase 1 Clinical |
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| References | References 1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86. 2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41. 3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60. 4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250. View Related Products by Target Bacterial Bacterial Infection |
| Molecular Formula | C9H18N4O8S |
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| Molecular Weight | 342.326 |
| Exact Mass | 342.084534 |
| 1,6-Diazabicyclo[3.2.1]octane-2-carboxamide, N-(2-aminoethoxy)-7-oxo-6-(sulfooxy)-, (2S,5R)-, hydrate (1:1) |
| (2S,5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide hydrate (1:1) |