ABD-1970

Modify Date: 2025-08-12 22:25:00

ABD-1970 Structure
ABD-1970 structure
 Common Name ABD-1970
CAS Number 2010154-82-0 Molecular Weight 515.881
Density N/A Boiling Point N/A
Molecular Formula C21H24ClF6N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ABD-1970


ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL); ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg; ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production.

 Names

Name ABD-1970

 ABD-1970 Biological Activity

Description ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL); ABD-1970 robustly elevated brain 2-AG content and displayed antinociceptive and anti-pruritic activity in a battery of rodent models (ED50 values of 1-2 mg/kg; ABD-1970 also blocked 2-AG hydrolysis in human brain tissue and elevated 2-AG content in human blood without affecting stimulated prostanoid production.
References References 1. Clapper JR, et al. J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.252296. View Related Products by Target Monoacylglycerol Lipase (MAGL)

 Chemical & Physical Properties

Molecular Formula C21H24ClF6N3O3
Molecular Weight 515.881
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