N,N-Dimethyl(2H3)acetamide

Modify Date: 2024-01-11 21:16:48

N,N-Dimethyl(2H3)acetamide Structure
N,N-Dimethyl(2H3)acetamide structure
Common Name N,N-Dimethyl(2H3)acetamide
CAS Number 20255-66-7 Molecular Weight 90.139
Density 0.9±0.1 g/cm3 Boiling Point 166.1±0.0 °C at 760 mmHg
Molecular Formula C4H6D3NO Melting Point N/A
MSDS N/A Flash Point 70.0±0.0 °C

 Use of N,N-Dimethyl(2H3)acetamide


N,N-Dimethylacetamide-d3 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].

 Names

Name n,n-dimethylacetamide-2,2,2-d3
Synonym More Synonyms

 N,N-Dimethyl(2H3)acetamide Biological Activity

Description N,N-Dimethylacetamide-d3 is the deuterium labeled N,N-Dimethylacetamide[1]. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Sundaram S, et al. N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183(2):422-30.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 166.1±0.0 °C at 760 mmHg
Molecular Formula C4H6D3NO
Molecular Weight 90.139
Flash Point 70.0±0.0 °C
Exact Mass 90.087242
PSA 20.31000
LogP -0.75
Vapour Pressure 1.8±0.3 mmHg at 25°C
Index of Refraction 1.407

 Synonyms

N,N-Dimethyl(H)acetamide
2,2,2-trideuterio-N,N-dimethyl-acetamide
2-<N,N-Dimethyl-acetamidinium>-thiosulfat
d3-N,N-Dimethylacetamid
N,N-Dimethyl-trideuteroacetamid
Acetamide-d, N,N-dimethyl-
N,N-Dimethyl-acetamidin-2-thiolsulfat
N,N-Dimethylacetamid-D3