BMS-192364

Modify Date: 2025-10-05 18:37:44

BMS-192364 structure	Common Name	BMS-192364
	CAS Number	202822-21-7	Molecular Weight	355.70
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₉ClF₃N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BMS-192364

BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].

Name	2-(5-chloro-2-hydroxyphenyl)-5-[4-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-3-one
Synonym	More Synonyms

Description	BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> GPCR/G Protein >> RGS Protein Research Areas >> Neurological Disease
References	[1]. Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57. [2]. Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38(4):344-54. [3]. David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80(3):233-5.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> GPCR/G Protein >> RGS Protein

Research Areas >> Neurological Disease

References

[1]. Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57.

[2]. Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38(4):344-54.

[3]. David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80(3):233-5.