IDO/TDO-IN-1

Modify Date: 2024-01-03 15:13:36

IDO/TDO-IN-1 structure	Common Name	IDO/TDO-IN-1
	CAS Number	2033173-01-0	Molecular Weight	413.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₄FN₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IDO/TDO-IN-1

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].

Name	IDO/TDO-IN-1

Description	IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]
In Vitro	IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].
References	[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.

Molecular Formula	C₂₅H₂₄FN₅
Molecular Weight	413.49

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: IDO/TDO-IN-1
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Purity: 98.0%
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