SNX-482

Modify Date: 2025-08-29 15:40:59

SNX-482 structure	Common Name	SNX-482
	CAS Number	203460-30-4	Molecular Weight	N/A
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉₂H₂₇₄N₅₂O₆₀S₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SNX-482

SNX-482, a peptidyl toxin of the spider Hysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect[1][2][3].

Name	SNX 482

Description	SNX-482, a peptidyl toxin of the spider Hysterocrates gigas, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
Target	IC50: 30 nM (CaV2.3 channel)[2]
References	[1]. R Newcomb, et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 1998 Nov 3;37(44):15353-62. [2]. E Bourinet, et al. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels. Biophys J. 2001 Jul;81(1):79-88. [3]. Elizabeth A Matthews, et al. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007 Jun;25(12):3561-9.

Molecular Formula	C₁₉₂H₂₇₄N₅₂O₆₀S₇
InChIKey	NSUPRLHDCFNOKD-CICZDBDCSA-N
SMILES	CSCCC1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(CCCNC(=N)N)NC(=O)C(NC(=O)CNC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(NC(=O)CN)C(C)C)CSSCC2NC(=O)C3CSSCC(C(=O)NC(C)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(Cc4ccccc4)C(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)O)C(C)O)NC(=O)C(Cc4ccc(O)cc4)NC(=O)C(CO)NC(=O)C(Cc4ccccc4)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(Cc4c[nH]cn4)NC(=O)C(CSSCC(NC(=O)CNC(=O)CNC(=O)C(Cc4ccccc4)NC1=O)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(CC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC(CC(=O)O)C(=O)N3)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C1CCCN1C2=O

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SNX 482
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: SNX-482
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.