ABX-1431 hydrochloride
Modify Date: 2024-09-29 15:44:27
ABX-1431 hydrochloride structure
|
Common Name | ABX-1431 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2043074-64-0 | Molecular Weight | 543.859 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H23ClF9N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ABX-1431 hydrochlorideABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical |
| Name | ABX-1431 hydrochloride |
|---|
| Description | ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical |
|---|---|
| References | References 1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951. View Related Products by Target Monoacylglycerol Lipase (MAGL) Pain |
| Molecular Formula | C20H23ClF9N3O2 |
|---|---|
| Molecular Weight | 543.859 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ABX-1431 hydrochloride
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: ABX-1431 hydrochloride
- Price: $700.0/100mg $1200.0/250mg $2100.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: ABX-1431 hydrochloride
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
Get all suppliers and price by the below link: