Dichloro-all-trans-retinone
Modify Date: 2024-04-06 01:29:14
Dichloro-all-trans-retinone structure
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Common Name | Dichloro-all-trans-retinone | ||
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| CAS Number | 2089135-65-7 | Molecular Weight | 367.354 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H28Cl2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dichloro-all-trans-retinoneDichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde. |
| Name | Dichloro-all-trans-retinone |
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| Description | Dichloro-all-trans-retinone (DAR) is an irreversible inhibitor of retinaldehyde dehydrogenase (RALDH/ALDH1A) with IC50 of 434/55/161 nM for RALDH1/RALDH2/RALDH3.Dichloro-all-trans-retinone has no activity on human mitochondrial ALDH2.Dichloro-all-trans-retinone inhibits ATRA synthesis in a RALDH2 expressing cell line with IC50 of 3 uM.The retinaldehyde dehydrogenase (RALDH, also ALDH1A) subfamily consists of three members, RALDH1 (ALDH1A1), RALDH2 (ALDH1A2), and RALDH3 (ALDH1A3), which synthesize all-trans-retinoic acid (ATRA) from retinaldehyde. |
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| References | 1. Angelica R Harper, et al. Bioorg Med Chem. 2018 Dec 1;26(22):5766-5779. |
| Molecular Formula | C21H28Cl2O |
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| Molecular Weight | 367.354 |