APHS
Modify Date: 2024-01-18 09:33:34
APHS structure
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Common Name | APHS | ||
|---|---|---|---|---|
| CAS Number | 209125-28-0 | Molecular Weight | 262.37 | |
| Density | 1.1g/cm3 | Boiling Point | 363.3ºC at 760mmHg | |
| Molecular Formula | C15H18O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 165.7ºC | |
Use of APHSAPHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition[1][2]. |
| Name | 2-(2-Heptynylthio)phenol Acetate |
|---|---|
| Synonym | More Synonyms |
| Description | APHS is a specific and covalent COX-2 inhibitor with neuroprotective effects. COX-2 is a prostaglandin (PG) synthetase overexpressed in colorectal cancer (CRC) and has pleiotropic cancer-promoting effects. APHS modifies COX-2 by acetylating the active site (serine 516), thereby inhibiting prostaglandin production. The neuroprotective activity of APHS is inhibited by prostaglandin E2. APHS also co-inhibits the WNT pathway, an anti-tumor mechanism in addition to COX-2 inhibition[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.1g/cm3 |
|---|---|
| Boiling Point | 363.3ºC at 760mmHg |
| Molecular Formula | C15H18O2S |
| Molecular Weight | 262.37 |
| Flash Point | 165.7ºC |
| Exact Mass | 262.10300 |
| PSA | 51.60000 |
| LogP | 3.51880 |
| Vapour Pressure | 1.82E-05mmHg at 25°C |
| Index of Refraction | 1.554 |
| (2-hept-2-ynylsulfanylphenyl) acetate |