Dihydroisotanshinone I
Modify Date: 2024-01-02 15:43:16
Dihydroisotanshinone I structure
|
Common Name | Dihydroisotanshinone I | ||
|---|---|---|---|---|
| CAS Number | 20958-18-3 | Molecular Weight | 278.302 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 479.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H14O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 214.9±28.8 °C | |
Use of Dihydroisotanshinone IDihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen. |
| Name | 4,8-dimethyl-8,9-dihydronaphtho[2,1-f][1]benzofuran-7,11-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen. |
|---|---|
| Related Catalog | |
| Target |
STAT3 |
| In Vitro | Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1[1]. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently[2]. |
| Cell Assay | Dihydroisotanshinone I is dissolved in ethyl acetate and mixed with the culture medium. The final concentration of ethyl acetate is 0.1% (v/v). Cell are treated with 2.5, 5, 10, and 20 μM dihydroisotanshinone I for 24 hours. The cell viability is measured using the MTT assay[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 479.2±45.0 °C at 760 mmHg |
| Molecular Formula | C18H14O3 |
| Molecular Weight | 278.302 |
| Flash Point | 214.9±28.8 °C |
| Exact Mass | 278.094299 |
| PSA | 43.37000 |
| LogP | 3.90 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.671 |
| HS Code | 2932999099 |
|---|
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 1,6-Dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione |
| Dihydrotanshinone |
| Dihydroisotanshinone I |
| Phenanthro[1,2-b]furan-10,11-dione, 1,2-dihydro-1,6-dimethyl- |
| Phenanthro[3,2-b]furan-7,11-dione,8,9-dihydro-4,8-dimethyl |
| 15,16-dihydroisotanshinone I |
- Shanghai Nianxing Industrial Co., Ltd
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- ShangHai DC Chemicals Co.,Ltd
- China
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- China
- Product Name: Dihydrotanshinone
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
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- Email: enquiry@dycnchem.com
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Price: $238/10mM*1mLinDMSO
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