Dihydroisotanshinone I

Modify Date: 2024-01-02 15:43:16

Dihydroisotanshinone I structure	Common Name	Dihydroisotanshinone I
	CAS Number	20958-18-3	Molecular Weight	278.302
	Density	1.3±0.1 g/cm3	Boiling Point	479.2±45.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	214.9±28.8 °C

Use of Dihydroisotanshinone I

Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.

Name	4,8-dimethyl-8,9-dihydronaphtho[2,1-f][1]benzofuran-7,11-dione
Synonym	More Synonyms

Description	Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.
Related Catalog	Research Areas >> Cancer Natural Products >> Quinones
Target	STAT3
In Vitro	Dihydroisotanshinone I can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone diminishes the ability of prostate cancer cells to recruit macrophages and reduces the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. It inhibits the protein expression of p-STAT3 and decreases the translocation of STAT3 into nuclear chromatin. It also suppresses the expression of tumor epithelial-mesenchymal transition genes, including RhoA and SNAI1[1]. Pretreating the cells with dihydroisotanshinone I at concentrations ranging from 2.5 μM to 20 μM for 24 hours cause dose-dependent protection against hepatotoxicity induced by menadione. Adding dihydroisotanshinone I to freshly isolated hepatocytes at concentrations between 50 nM to 200 nM inhibit NADH-induced superoxide production dose-dependently[2].
Cell Assay	Dihydroisotanshinone I is dissolved in ethyl acetate and mixed with the culture medium. The final concentration of ethyl acetate is 0.1% (v/v). Cell are treated with 2.5, 5, 10, and 20 μM dihydroisotanshinone I for 24 hours. The cell viability is measured using the MTT assay[2].
References	[1]. Wu CY, et al. Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway. Oncotarget. 2017 Feb 1. [2]. Ip SP, et al. Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytes. Planta Med. 2002 Dec;68(12):1077-81.

Density	1.3±0.1 g/cm3
Boiling Point	479.2±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₄O₃
Molecular Weight	278.302
Flash Point	214.9±28.8 °C
Exact Mass	278.094299
PSA	43.37000
LogP	3.90
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.671

HS Code	2932999099

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1,6-Dimethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione

Dihydrotanshinone

Dihydroisotanshinone I

Phenanthro[1,2-b]furan-10,11-dione, 1,2-dihydro-1,6-dimethyl-

Phenanthro[3,2-b]furan-7,11-dione,8,9-dihydro-4,8-dimethyl

15,16-dihydroisotanshinone I

BioBioPha
China
Product Name: Dihydroisotanshinone I
Price: ￥3900.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Dihydroisotanshinone I
Price: ￥248.0/20mg ￥3438.0/5mg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Dihydroisotanshinone I
Price: $800.0/100mg $1600.0/250mg $3200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Dihydrotanshinone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $238/10mM*1mLinDMSO

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