KRpep-2d
Modify Date: 2025-08-25 17:58:20
KRpep-2d structure
|
Common Name | KRpep-2d | ||
|---|---|---|---|---|
| CAS Number | 2098181-84-9 | Molecular Weight | 2560.02 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C109H183N43O25S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRpep-2dKRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1]. |
| Name | KRpep-2d |
|---|
| Description | KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1]. |
|---|---|
| Related Catalog | |
| Target |
K-RAS |
| In Vitro | KRpep-2d has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1]. KRpep-2d (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1]. |
| References |
| Molecular Formula | C109H183N43O25S2 |
|---|---|
| Molecular Weight | 2560.02 |
| InChIKey | PNSDZPKWIOBSHR-WVEXBLHFSA-N |
| SMILES | CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(CC(C)C)NC(=O)C2CCCN2C(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(N)CCCNC(=N)NC(C)=O)CSSCC(C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(N)=O)NC(=O)C(C(C)C)NC(=O)C2CCCN2C(=O)C(CC(=O)O)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(CO)NC1=O |