CM03
Modify Date: 2025-08-25 12:33:10
CM03 structure
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Common Name | CM03 | ||
|---|---|---|---|---|
| CAS Number | 2101208-44-8 | Molecular Weight | 632.762 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H44N6O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CM03CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine. |
| Name | CM03 |
|---|
| Description | CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM); CM03 shows >20-fold selectivity for MIA PaCa-2 compared to MCF-7 cells, also shows greater selectivity than MM41 relative to the non-oncogenic control fibroblasts; demonstrates anticancer activity in PDAC models, with a superior profile compared to gemcitabine. |
|---|---|
| References | References 1. Marchetti C, et al. J Med Chem. 2018 Feb 7. doi: 10.1021/acs.jmedchem.7b01781. View Related Products by Target DNA Alkylator/Crosslinker |
| Molecular Formula | C34H44N6O6 |
|---|---|
| Molecular Weight | 632.762 |
| InChIKey | WHLXIQNGOLIDJQ-UHFFFAOYSA-N |
| SMILES | O=c1c2c(=NCCN3CCCC3)cc3c(=O)n(CCCN4CCOCC4)c(=O)c4ccc(c(O)n1CCCN1CCOCC1)c2c4-3 |