8-Chloroguanosine

Modify Date: 2024-01-03 10:53:39

8-Chloroguanosine Structure
8-Chloroguanosine structure
Common Name 8-Chloroguanosine
CAS Number 2104-68-9 Molecular Weight 317.69
Density 2.35 g/cm3 Boiling Point 764.7ºC at 760 mmHg
Molecular Formula C10H12ClN5O5 Melting Point N/A
MSDS N/A Flash Point 416.3ºC

 Use of 8-Chloroguanosine


8-Chloroguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-amino-8-chloro-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonym More Synonyms

 8-Chloroguanosine Biological Activity

Description 8-Chloroguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 2.35 g/cm3
Boiling Point 764.7ºC at 760 mmHg
Molecular Formula C10H12ClN5O5
Molecular Weight 317.69
Flash Point 416.3ºC
Exact Mass 317.05300
PSA 159.51000
Vapour Pressure 1.38E-24mmHg at 25°C
Index of Refraction 1.956

 Synonyms

Guanosine,8-chloro
8-Chloroguanosine
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