4-DeMethyltriMethopriM
Modify Date: 2024-01-27 12:12:33
4-DeMethyltriMethopriM structure
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Common Name | 4-DeMethyltriMethopriM | ||
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| CAS Number | 21253-58-7 | Molecular Weight | 276.29 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 567.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C13H16N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 296.9±32.9 °C | |
Use of 4-DeMethyltriMethopriM4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1]. |
| Name | 4-[(2,4-Diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenol |
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| Synonym | More Synonyms |
| Description | 4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1]. |
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| Related Catalog | |
| Target |
Ki: 5.1 nM (WT), 34.3 nM (L28R)[1] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.4±60.0 °C at 760 mmHg |
| Molecular Formula | C13H16N4O3 |
| Molecular Weight | 276.29 |
| Flash Point | 296.9±32.9 °C |
| Exact Mass | 276.122253 |
| LogP | -0.09 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.652 |
| 4-[(2,4-Diamino-5-pyrimidinyl)methyl]-2,6-dimethoxyphenol |
| 4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenol |
| Phenol, 4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxy- |