CYP4A11/CYP4F2-IN-2
Modify Date: 2025-08-31 08:44:46
CYP4A11/CYP4F2-IN-2 structure
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Common Name | CYP4A11/CYP4F2-IN-2 | ||
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| CAS Number | 2126874-77-7 | Molecular Weight | 300.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H20N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CYP4A11/CYP4F2-IN-2CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1]. |
| Name | CYP4A11/CYP4F2-IN-2 |
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| Description | CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 has potential for the research of renal diseases[1]. |
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| Related Catalog | |
| Target |
CYP4A11:140 nM (IC50) CYP4F2:40 nM (IC50) |
| In Vitro | CYP4A11/CYP4F2-IN-2 (compound 11c) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 29 nM[1]. |
| In Vivo | CYP4A11/CYP4F2-IN-2 (compound 11c) (0.03-1 mg/kg; a single p.o.) inhibits renal 20-HETE production of rats in a dose-dependent manner[1]. CYP4A11/CYP4F2-IN-2 (0.5 mg/kg; i.v.) exhibits low CL (1430 mL/h/kg), moderate Vdss(763 mL/kg), and short T1/2 (0.424 h) in mice[1]. CYP4A11/CYP4F2-IN-2 (1 mg/kg; i.v.) exhibits low CL (226 mL/h/kg), moderate Vdss(839 mL/kg), and T1/2 (3.01 h) in SD rats[1]. CYP4A11/CYP4F2-IN-2 (1 mg/kg; p.o.) exhibits Cmax (623 ng/mL), T1/2 (3.03 h), and high bioavailability (97.7%) in SD rats[1]. |
| References |
| Molecular Formula | C16H20N4O2 |
|---|---|
| Molecular Weight | 300.36 |
| InChIKey | GNQGSUOEYQIORN-UHFFFAOYSA-N |
| SMILES | CC(=O)N1CCC(COc2ccc(-c3ccn[nH]3)nc2)CC1 |