Fostroxacitabine bralpamide

Modify Date: 2024-01-12 11:33:09

Fostroxacitabine bralpamide Structure
Fostroxacitabine bralpamide structure
Common Name Fostroxacitabine bralpamide
CAS Number 2129993-56-0 Molecular Weight 589.37
Density N/A Boiling Point N/A
Molecular Formula C22H30BrN4O8P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Fostroxacitabine bralpamide


Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects[1].

 Names

Name Fostroxacitabine bralpamide

 Fostroxacitabine bralpamide Biological Activity

Description Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide prodrug. Fostroxacitabine bralpamide has anticancer effects[1].
Related Catalog
In Vitro Fostroxacitabine bralpamide (MIV-818) is highly metabolized by human hepatocytes, directing high levels of the chain-terminating nucleotide tri-phosphate to the liver. The tri-phosphate is incorporated into DNA during replication, which leads to DNA double strand breaks, DNA damage responses, and cytotoxicity[1].
References

[1]. T.R. Jeffry Evans, et al. Phase I study of the novel pro-drug MIV-818 in patients with hepatocellular carcinoma, intra-hepatic cholangiocarcinoma or liver metastases.

 Chemical & Physical Properties

Molecular Formula C22H30BrN4O8P
Molecular Weight 589.37
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