STING agonist-3
Modify Date: 2024-01-11 18:41:19
STING agonist-3 structure
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Common Name | STING agonist-3 | ||
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| CAS Number | 2138299-29-1 | Molecular Weight | 750.81 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H42N12O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STING agonist-3STING agonist-3 is a selective small-molecule STING agonist. STING agonist-3 is a non-nucleotide STING agonist which has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1]. |
| Name | STING agonist-3 |
|---|
| Description | STING agonist-3 is a selective small-molecule STING agonist. STING agonist-3 is a non-nucleotide STING agonist which has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1]. |
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| Related Catalog | |
| In Vitro | STING agonist-3 (Compound 3) induces dose-dependent activation of STING and secretion of IFN-β with ECapp50s of 130 nM,186 nM in human PBMCs and Mouse PBMCs[1]. |
| In Vivo | STING agonist-3 (Compound 3) (subcutaneous injection; 2.5mg/kg) activates secretion of IFN-β, IL-6, TNF-α, and KC/GROα (CXCL1) in wild-type but not Sting−/− mice, induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo[1]. STING agonist-3 (Compound 3) (subcutaneous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations with EC50=200 ng /ml for mouse STING[1]. STING agonist-3 (Compound 3) (injection intravenously; 1.5 mg/kg) results in significant tumor growth inhibition, and improves survival with 8 out of 10 mice remaining tumors free at day 43[1]. Animal Model: Mice with approximately 100 mm3 subcutaneous CT-26 tumors[1] Dosage: 1.5 mg/kg Administration: Injection intravenously; 1.5 mg/kg; 1 day, 4 days, 8 days Result: Resulted in significant tumor growth inhibition. |
| References |
| Molecular Formula | C37H42N12O6 |
|---|---|
| Molecular Weight | 750.81 |