2BAct
Modify Date: 2025-08-23 22:12:11
2BAct structure
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Common Name | 2BAct | ||
|---|---|---|---|---|
| CAS Number | 2143542-28-1 | Molecular Weight | 440.807 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16ClF3N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 2BAct2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays; 2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice; also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice. |
| Name | 2BAct |
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| Description | 2BAct (eIF2B activator 2BAct) is a novel, highly selective, CNS-permeable small molecule eIF2B activator with EC50 of 33 nM in cell-based reporter assays; 2BAct normalized body weight gain and prevented motor deficits in male R191H mice, prevented myelin loss and reactive gliosis in the brain and spinal cord of R191H mice; also prevented ISR induction in the cerebellum and spinal cord of Eif2b5R132H/R132H mice, prevented all measures of pathology and normalizes the transcriptome and proteome of Vanishing White Matter (VWM) mice. |
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| References | References 1. Wong YL, et al. Elife. 2019 Jan 9;8. pii: e42940. doi: 10.7554/eLife.42940. View Related Products by Target Eukaryotic Initiation Factor (eIF) |
| Molecular Formula | C19H16ClF3N4O3 |
|---|---|
| Molecular Weight | 440.807 |