ICT5040

Modify Date: 2025-08-25 21:45:27

ICT5040 structure	Common Name	ICT5040
	CAS Number	215655-21-3	Molecular Weight	275.250
	Density	1.5±0.1 g/cm3	Boiling Point	343.5±52.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₈F₃N₃OS	Melting Point	N/A
	MSDS	N/A	Flash Point	161.5±30.7 °C

Use of ICT5040

ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].

Name	2-(methylthio)-5-[2-methyl-6-(trifluoromethyl)-3-pyridyl]-1,3,4-oxadiazole
Synonym	More Synonyms

Description	ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR
Target	CXCR4:3.8 μM (IC50)
In Vitro	ICT5040 (1-100 μM; 0-4 d) 剂量依赖性地抑制 CXCL12 诱导的 U87 胶质瘤细胞的增殖和迁移[1]。 ICT5040 在 U87 胶质瘤细胞中降低 CXCL12 诱导的细胞内钙动员[1]。 Cell Migration Assay [1] Cell Line: U87-glioma cells Concentration: 1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12 Incubation Time: 0, 1, 2, 3, and 4 days Result: Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3.
References	[1]. Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8(10):e78744.

Density	1.5±0.1 g/cm3
Boiling Point	343.5±52.0 °C at 760 mmHg
Molecular Formula	C₁₀H₈F₃N₃OS
Molecular Weight	275.250
Flash Point	161.5±30.7 °C
Exact Mass	275.034027
LogP	3.75
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.543

Pyridine, 2-methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)-

2-(methylthio)-5-[2-methyl-6-(trifluoromethyl)-3-pyridyl]-1,3,4-oxadiazole

2-Methyl-3-[5-(methylsulfanyl)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)pyridine

2-Methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)pyridine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ICT5040
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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ICT5040

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.