ICT5040
Modify Date: 2024-03-31 13:43:54
ICT5040 structure
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Common Name | ICT5040 | ||
|---|---|---|---|---|
| CAS Number | 215655-21-3 | Molecular Weight | 275.250 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 343.5±52.0 °C at 760 mmHg | |
| Molecular Formula | C10H8F3N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 161.5±30.7 °C | |
Use of ICT5040ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1]. |
| Name | 2-(methylthio)-5-[2-methyl-6-(trifluoromethyl)-3-pyridyl]-1,3,4-oxadiazole |
|---|---|
| Synonym | More Synonyms |
| Description | ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1]. |
|---|---|
| Related Catalog | |
| Target |
CXCR4:3.8 μM (IC50) |
| In Vitro | ICT5040 (1-100 μM; 0-4 d) 剂量依赖性地抑制 CXCL12 诱导的 U87 胶质瘤细胞的增殖和迁移[1]。 ICT5040 在 U87 胶质瘤细胞中降低 CXCL12 诱导的细胞内钙动员[1]。 Cell Migration Assay [1] Cell Line: U87-glioma cells Concentration: 1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12 Incubation Time: 0, 1, 2, 3, and 4 days Result: Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 343.5±52.0 °C at 760 mmHg |
| Molecular Formula | C10H8F3N3OS |
| Molecular Weight | 275.250 |
| Flash Point | 161.5±30.7 °C |
| Exact Mass | 275.034027 |
| LogP | 3.75 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.543 |
| Pyridine, 2-methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)- |
| 2-(methylthio)-5-[2-methyl-6-(trifluoromethyl)-3-pyridyl]-1,3,4-oxadiazole |
| 2-Methyl-3-[5-(methylsulfanyl)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)pyridine |
| 2-Methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)pyridine |