Z-Ala-Pro-Phe-chloromethylketone

Modify Date: 2024-01-28 06:44:27

Z-Ala-Pro-Phe-chloromethylketone Structure
Z-Ala-Pro-Phe-chloromethylketone structure
Common Name Z-Ala-Pro-Phe-chloromethylketone
CAS Number 217658-18-9 Molecular Weight 499.987
Density 1.3±0.1 g/cm3 Boiling Point 754.9±60.0 °C at 760 mmHg
Molecular Formula C26H30ClN3O5 Melting Point N/A
MSDS N/A Flash Point 410.3±32.9 °C

 Use of Z-Ala-Pro-Phe-chloromethylketone


Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP)[1].

 Names

Name N-[(Benzyloxy)carbonyl]-L-alanyl-N-[(2S)-4-chloro-3-oxo-1-phenyl-2-butanyl]-L-prolinamide
Synonym More Synonyms

 Z-Ala-Pro-Phe-chloromethylketone Biological Activity

Description Z-APF-CMK is a specific inhibitor of Ca2+-regulated nuclear scaffold protease (CRNSP)[1].
Related Catalog
References

[1]. Zhang D, et al. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5746-51.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 754.9±60.0 °C at 760 mmHg
Molecular Formula C26H30ClN3O5
Molecular Weight 499.987
Flash Point 410.3±32.9 °C
Exact Mass 499.187408
LogP 4.01
Vapour Pressure 0.0±2.5 mmHg at 25°C
Index of Refraction 1.581

 Synonyms

L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-alanyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-
N-[(Benzyloxy)carbonyl]-L-alanyl-N-[(2S)-4-chloro-3-oxo-1-phenyl-2-butanyl]-L-prolinamide