Benzcyclane

Modify Date: 2024-01-06 18:19:04

Benzcyclane Structure
Benzcyclane structure
Common Name Benzcyclane
CAS Number 2179-37-5 Molecular Weight 289.45600
Density 0.97g/cm3 Boiling Point 384.2ºC at 760mmHg
Molecular Formula C19H31NO Melting Point N/A
MSDS N/A Flash Point 113.2ºC

 Use of Benzcyclane


Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.

 Names

Name 3-(1-benzylcycloheptyl)oxy-N,N-dimethylpropan-1-amine
Synonym More Synonyms

 Benzcyclane Biological Activity

Description Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.
Related Catalog
In Vivo Benzcyclane, although capable of aggregating platelets by itself at very high concentrations, shows a striking inhibitory effect, over a wide range of concentrations, both on platelet aggregation induced by ADP, epinephrine or collagen and on platelet adhesiveness to glass or collagen. Clot retraction is also clearly inhibited[1]. Benzcyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels[2].
References

[1]. Ponari O, et al. In vitro effects of bencyclan on coagulation, fibrinolysis and platelet function. Arzneimittelforschung. 1976;26(8):1532-8.

[2]. Nánási PP, et al. Effects of bencyclane on normal and cevadine-modified Na channels in frog skeletal muscle. Gen Physiol Biophys. 1989 Oct;8(5):447-58.

 Chemical & Physical Properties

Density 0.97g/cm3
Boiling Point 384.2ºC at 760mmHg
Molecular Formula C19H31NO
Molecular Weight 289.45600
Flash Point 113.2ºC
Exact Mass 289.24100
PSA 12.47000
LogP 4.29040
Vapour Pressure 4.17E-06mmHg at 25°C
Index of Refraction 1.52
Storage condition 2-8℃

 Safety Information

HS Code 2922199090

 Synthetic Route

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Benzcyclane Structure

Benzcyclane

CAS#:2179-37-5

Literature: Pallos; Budai; Zolyomi Arzneimittel-Forschung, 1972 , vol. 22, # 9 p. 1502 - 1505

 Customs

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Benzcyclan
EINECS 218-547-0
BENCYCLANE
Benzcyclane