VU6005806

Modify Date: 2024-01-09 17:13:54

VU6005806 structure	Common Name	VU6005806
	CAS Number	2180914-37-6	Molecular Weight	439.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₆F₃N₇O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of VU6005806

VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1].

Name	VU6005806

Description	VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	IC50: 94 nM (Human M4), 28 nM (Rat M4), 87 nM (Dog M4), 68 nM (Cyno M4)[1]
References	[1]. Engers DW, et al. VU6005806/AZN-00016130, an advanced M4 positive allosteric modulator (PAM) profiled as a potential preclinical development candidate. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1714-1718.

Molecular Formula	C₁₇H₁₆F₃N₇O₂S
Molecular Weight	439.41

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: VU6005806
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Purity: 98.0%
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