Euphorbia factor L3

Modify Date: 2024-01-02 03:36:29

Euphorbia factor L3 Structure
Euphorbia factor L3 structure
Common Name Euphorbia factor L3
CAS Number 218916-52-0 Molecular Weight 522.629
Density 1.2±0.1 g/cm3 Boiling Point 595.5±50.0 °C at 760 mmHg
Molecular Formula C31H38O7 Melting Point N/A
MSDS N/A Flash Point 249.0±30.2 °C

 Use of Euphorbia factor L3


5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

 Names

Name Diacetyl benzoyl lathyrol
Synonym More Synonyms

 Euphorbia factor L3 Biological Activity

Description 5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.
Related Catalog
In Vitro 5,15-Diacetyl-3-benzoyllathyrol shows anticancer activity in vitro against lung cancer A549 cells and the IC50 values are 34.04±3.99 μM. Furthermore, 5,15-Diacetyl-3-benzoyllathyrol can induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c[1].
Cell Assay Cells are harvested during logarithmic growth phase and seeded in 96-well plates at a density of 1.5×104 cells/mL of final volume 190 μL/well. After incubation of 24 h, 10 μL EFL3 solution of full range concentrations is added to 96-well plates. After 68 h treatment, 10 μL MTT of 10 mM is added to each well for 4 h of maintaining at 37°C. Then, the supernatant is removed and the crystals are dissolved with 100 μL anhydrous DMSO each well. Subsequently, cell viability is measured by Model 550 Microplate reader at 540 nm and 655 nm as reference filter. Experiments are carried out at least thrice. The 50% inhibitory concentration (IC50) is defined as the anticancer agent concentration causing 50% reduction in cell viability and calculated from the cytotoxicity curves. Cell survival is calculated with the following formula: survival (%)=(mean experimental absorbance/mean control absorbance) × 100%.
References

[1]. Zhang JY, et al. Structure identification of Euphorbia factor L3 and its induction of apoptosis through the mitochondrial pathway. Molecules. 2011 Apr 15;16(4):3222-31.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 595.5±50.0 °C at 760 mmHg
Molecular Formula C31H38O7
Molecular Weight 522.629
Flash Point 249.0±30.2 °C
Exact Mass 522.261780
PSA 95.97000
LogP 7.25
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.557
Storage condition -20℃

 Synonyms

(1aR,2E,4aR,6S,7S,7aR,8R,11aS)-4a,8-Diacetoxy-1,1,3,6-tetramethyl-9-methylene-4-oxo-1a,4,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1H-cyclopenta[a]cyclopropa[f][11]annulen-7-yl benzoate
5,15-Diacetyl-3-benzoyllathyrol
Euphorbia factor L3
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4H-Cyclopenta[a]cyclopropa[f]cycloundecen-4-one, 4a,8-bis(acetyloxy)-7-(benzoyloxy)-1,1a,4a,5,6,7,7a,8,9,10,11,11a-dodecahydro-1,1,3,6-tetramethyl-9-methylene-, (1aR,2E,4aR,6S,7S,7aR,8R,11aS)-
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