Labetuzumab

Modify Date: 2024-01-08 17:28:47

Labetuzumab Structure
Labetuzumab structure
Common Name Labetuzumab
CAS Number 219649-07-7 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Labetuzumab


Labetuzumab is a humanised anti-carcinoembryonic antigen (CEA) monoclonal antibody that inhibits tumour growth and sensitises human medullary thyroid cancer xenografts to Dacarbazine chemotherapy[1].

 Names

Name Labetuzumab

 Labetuzumab Biological Activity

Description Labetuzumab is a humanised anti-carcinoembryonic antigen (CEA) monoclonal antibody that inhibits tumour growth and sensitises human medullary thyroid cancer xenografts to Dacarbazine chemotherapy[1].
Related Catalog
Target

CEA[1].

In Vivo Labetuzumab (0.5 mg/rat; i.v.; single) inhibits tumor growth in vivo[1]. Animal Model: Female nu/nu mice (6 to 8-week-old; inject TT cells)[1]. Dosage: 0.5 mg/rat Administration: Intravenous injection; single (1 day post-tumor cell injection) Result: Significantly delaied growth of tumor, and led to 64%-70% inhibition of tumor size between days 32 and 60.
References

[1]. Stein R, et al. A humanized monoclonal antibody to carcinoembryonic antigen, labetuzumab, inhibits tumor growth and sensitizes human medullary thyroid cancer xenografts to dacarbazine chemotherapy. Mol Cancer Ther. 2004 Dec;3(12):1559-64.

 Chemical & Physical Properties

No Any Chemical & Physical Properties