GSK3395879

Modify Date: 2025-12-27 08:26:49

GSK3395879 structure	Common Name	GSK3395879
	CAS Number	2215852-91-6	Molecular Weight	485.41
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₅F₄N₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GSK3395879

GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4[1].

Name	GSK3395879

Description	GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC50 of 1 nM for hTRPV4[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease
Target	IC50: 1 nM (hTRPV4)[1]
References	[1]. Brnardic EJ, et al. Discovery of Pyrrolidine Sulfonamides as Selective and Orally Bioavailable Antagonists of Transient Receptor Potential Vanilloid-4 (TRPV4). J Med Chem. 2018 Nov 8;61(21):9738-9755.

Molecular Formula	C₂₀H₁₅F₄N₃O₅S
Molecular Weight	485.41
InChIKey	RAYCYIKGBWRQBC-RBUKOAKNSA-N
SMILES	N#Cc1ccc(OC2CN(S(=O)(=O)c3ccc(C(F)(F)F)cc3C#N)CC2(O)CO)cc1F

Name: Ratio of Cmax to Cmin in human
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322961

Name: Drug metabolism in rat hepatocytes assessed as oxidation of arene oxide metabolite by...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322958

Name: Drug metabolism in rat hepatocytes assessed as rearomatization/conjugation by measuri...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322957

Name: Drug metabolism in rat hepatocytes assessed as GSH-mediated sulfonamide cleavage by m...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322956

Name: Ratio of unbound clearance in Sprague-Dawley rat at 1 mg/kg, iv administered as 30 mi...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322955

Name: In vivo antagonist activity at TRPV4 in iv dosed Sprague-Dawley rat assessed as inhib...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL4158460

Name: In vivo antagonist activity at TRPV4 in iv dosed Sprague-Dawley rat assessed as inhib...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL4158461

Name: In vivo antagonist activity at TRPV4 in iv dosed Sprague-Dawley rat assessed as inhib...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL4158462

Name: Oral bioavailability in Sprague-Dawley rat at 1 mg/kg by HPLC-MS/MS analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322943

Name: Dose normalized AUC in Sprague-Dawley rat at 1 mg/kg, po by HPLC-MS/MS analysis
Source: ChEMBL
Target: N/A
External Id: CHEMBL4322942

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK3395879
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Purity: 98.0%
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Contact: Yang
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.