SOS1 activator 1

Modify Date: 2025-08-25 16:28:06

SOS1 activator 1 Structure
SOS1 activator 1 structure
Common Name SOS1 activator 1
CAS Number 2245237-53-8 Molecular Weight 483.02
Density N/A Boiling Point N/A
Molecular Formula C26H32ClFN6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SOS1 activator 1


SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS[1].

 Names

Name SOS1 activator 1

 SOS1 activator 1 Biological Activity

Description SOS1 activator 1 (Compound 64) is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS[1].
Related Catalog
References

[1]. Timothy R Hodges, et al. Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. J Med Chem. 2018 Oct 11;61(19):8875-8894.

 Chemical & Physical Properties

Molecular Formula C26H32ClFN6
Molecular Weight 483.02
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.