Nvs-pak1-c
Modify Date: 2025-08-27 09:41:56
Nvs-pak1-c structure
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Common Name | Nvs-pak1-c | ||
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| CAS Number | 2250019-95-3 | Molecular Weight | 465.90 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23ClF3N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Nvs-pak1-cNVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1]. |
| Name | NVS-PAK1-C |
|---|
| Description | NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1]. |
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| Related Catalog | |
| Target |
PAK1:0.007 μM (Kd) PAK2:0.4 μM (Kd) PAK1:5 nM (IC50) PAK2:270 nM (IC50) |
| In Vitro | NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1]. |
| References |
| Molecular Formula | C22H23ClF3N5O |
|---|---|
| Molecular Weight | 465.90 |