Icapamespib HCl
Modify Date: 2025-09-19 12:07:42
Icapamespib HCl structure
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Common Name | Icapamespib HCl | ||
|---|---|---|---|---|
| CAS Number | 2267287-26-1 | Molecular Weight | 599.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H25Cl2IN6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Icapamespib HClIcapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans. |
| Name | Icapamespib HCl |
|---|
| Description | Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans. |
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| Molecular Formula | C19H25Cl2IN6O2S |
|---|---|
| Molecular Weight | 599.31 |
| InChIKey | XOTDTJJJOBBSFU-UHFFFAOYSA-N |
| SMILES | CC(C)(C)CNCCn1c(Sc2cc3c(cc2I)OCO3)nc2c(N)ncnc21.Cl.Cl |