Taltobulin intermediate-1

Modify Date: 2025-08-25 10:54:39

Taltobulin intermediate-1 Structure
Taltobulin intermediate-1 structure
Common Name Taltobulin intermediate-1
CAS Number 228266-38-4 Molecular Weight 307.39
Density 1.107±0.06 g/cm3(Predicted) Boiling Point 419.6±34.0 °C(Predicted)
Molecular Formula C17H25NO4 Melting Point N/A
MSDS N/A Flash Point 207.6±25.7 °C

 Use of Taltobulin intermediate-1


Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

 Names

Name L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N,β,β-trimethyl-
Synonym More Synonyms

 Taltobulin intermediate-1 Biological Activity

Description Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
Related Catalog
References

[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.  

 Chemical & Physical Properties

Density 1.107±0.06 g/cm3(Predicted)
Boiling Point 419.6±34.0 °C(Predicted)
Molecular Formula C17H25NO4
Molecular Weight 307.39
Flash Point 207.6±25.7 °C
Exact Mass 307.178345
LogP 4.15
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.518

 Synonyms

L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-N,β,β-trimethyl-
N,β,β-Trimethyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-phenylalanine
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