Apelin-12

Modify Date: 2025-08-22 10:36:23

Apelin-12 structure	Common Name	Apelin-12
	CAS Number	229961-08-4	Molecular Weight	1422.70000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₄H₁₀₃N₂₁O₁₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Apelin-12

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].

Name	H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
Synonym	More Synonyms

Description	Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1]. Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2]. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4].
References	[1]. Pisarenko OI, et al. Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J Pharmacol Pharmacother. 2013;4(3):198-203. [2]. Pisarenko OI, et al. Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem. 2014;391(1-2):241-250. [3]. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. Liu DR, et al. Apelin-12 exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and P38MAPK signaling pathway in mouse. Eur Rev Med Pharmacol Sci. 2018;22(12):3888-3895. [4]. Ohno S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept. 2012;174(1-3):71-78.

Molecular Formula	C₆₄H₁₀₃N₂₁O₁₄S
Molecular Weight	1422.70000
Exact Mass	1421.77000
PSA	581.08000
LogP	2.26000
Storage condition	-20°C

Apelin-12 (huMan,bovine,Mouse,rat) (Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat)

APELIN PRECURSOR (66-77) (HUMAN,BOVINE,MOUSE,RAT)

ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE

APELIN 12

(DES-GLN1)-APELIN-13 (HUMAN,BOVINE,MOUSE,RAT)

(Des-Gln1)-Apelin-13 (huMan,bovine,Mouse,rat),Apelin Precursor (66-77) (huMan,bovine,Mouse,rat),Preproapelin (66-77) (huMan,bovine,Mouse,rat)

RPRLSHKGPMPF

APELIN-12 (HUMAN,BOVINE,MOUSE,RAT)

H-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH

PREPROAPELIN (66-77) (HUMAN,BOVINE,MOUSE,RAT)