DMX-5804
DMX-5804 structure
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Common Name | DMX-5804 | ||
|---|---|---|---|---|
| CAS Number | 2306178-56-1 | Molecular Weight | 361.39 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DMX-5804DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1]. |
| Name | DMX-5804 |
|---|
| Description | DMX-5804 is a potent, orally active and selective MAP4K4 inhibitor, with an IC50 of 3 nM, a pIC50 of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96). DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice[1]. |
|---|---|
| Related Catalog | |
| Target |
MAP4K4:3 nM (IC50) MAP4K4:8.55 (pIC50) MINK1/MAP4K6:8.18 (pIC50) TNIK/MAP4K7:7.96 (pIC50) GCK/MAP4K2:6.50 (pIC50) KHS/MAP4K5:6.36 (pIC50) GLK/MAP4K3:4.95 (pIC50) MLK1/MAP3K9:7.19 (pIC50) MLK3/MAP3K11:6.99 (pIC50) NUAK:6.88 (pIC50) VEGFR:5.72 (pIC50) ABL1:5.80 (pIC50) Aurora B:5.49 (pIC50) FLT3:5.31 (pIC50) GSK3β:4.66 (pIC50) |
| In Vitro | DMX-5804 exhibits great selectivity at MAP4K4 over other kinases, such as GCK/MAP4K2 (pIC50, 6.50), GLK/MAP4K3 (pIC50, 4.95), KHS/MAP4K5 (pIC50, 6.36), ABL1 (pIC50, 5.80), Aurora B (pIC50, 5.49), FLT3 (pIC50, 5.31), GSK3β (pIC50, 4.66), MLK1/MAP3K9 (pIC50, 7.19), MLK3/MAP3K11 (pIC50, 6.99), NUAK (pIC50, 6.88) and VEGFR (pIC50, 5.72)[1]. |
| References |
| Molecular Formula | C21H19N3O3 |
|---|---|
| Molecular Weight | 361.39 |
| Storage condition | 2-8℃ |