HI-236

Modify Date: 2025-08-26 22:26:10

HI-236 structure	Common Name	HI-236
	CAS Number	233271-65-3	Molecular Weight	396.3
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₈BrN₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HI-236

HI-236 is used as a non-nucleoside HIV-1 reverse-transcriptase inhibitor.

Name	HI-236

Description	HI-236 is used as a non-nucleoside HIV-1 reverse-transcriptase inhibitor.
References	1. Younis Y, Hunter R, Muhanji CI, Hale I, Singh R, Bailey CM, Sullivan TJ, Anderson KS. [d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase. Bioorg Med Chem. 2010 Jul 1;18(13):4661-73. doi: 10.1016/j.bmc.2010.05.025. Epub 2010 May 11. PubMed PMID: 20605472; PubMed Central PMCID: PMC2964380.

Molecular Formula	C₁₆H₁₈BrN₃O₂S
Molecular Weight	396.3
InChIKey	GNLVRKKIIIVZHZ-UHFFFAOYSA-N
SMILES	COc1ccc(OC)c(CCNC(=S)Nc2ccc(Br)cn2)c1

Name: Cytotoxicity against human MT2 cells after 5 days by MTT assay
Source: ChEMBL
Target: MT2
External Id: CHEMBL1177073

Name: Therapeutic index, ratio of CC50 for HIV1 Y181C mutant infected human MT2 cells to EC...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1010082

Name: Inhibition of HIV1 3B reverse transcriptase
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1010079

Name: Cytotoxicity against mock-infected human MT2 cells after 5 days by MTT assay
Source: ChEMBL
Target: MT2
External Id: CHEMBL1010077

Name: Therapeutic index, ratio of CC50 for human MT2 cells to EC50 for HIV1 3B
Source: ChEMBL
Target: N/A
External Id: CHEMBL1010078

Name: Antiviral activity against nevirapine-resistant HIV1 3B infected in human MT2 cells a...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL1010076

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Therapeutic index, ratio of IC50 for human MT2 cells to EC50 for HIV1 3B
Source: ChEMBL
Target: N/A
External Id: CHEMBL886685

Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data

Name: Inhibition of HIV1 reverse transcriptase-mediated thymidine incorporation into D23/D3...
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1177074

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HI-236

Use of HI-236

Names

HI-236 Biological Activity

Chemical & Physical Properties

HI-236Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.