PROTAC ER Degrader-4
Modify Date: 2025-08-27 11:47:00
PROTAC ER Degrader-4 structure
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Common Name | PROTAC ER Degrader-4 | ||
|---|---|---|---|---|
| CAS Number | 2361114-15-8 | Molecular Weight | 1005.19 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C53H67F3N6O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC ER Degrader-4PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1]. |
| Name | PROTAC ER Degrader-4 |
|---|
| Description | PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
VHL ER |
| In Vitro | PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1]. |
| References |
[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1. |
| Molecular Formula | C53H67F3N6O8S |
|---|---|
| Molecular Weight | 1005.19 |
| InChIKey | WNWBHGDKGOSOKU-QIINAUKOSA-N |
| SMILES | Cc1ncsc1-c1ccc(C(C)NC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCOCCOCCOc2cc(F)c(C3c4[nH]c5ccccc5c4CC(C)N3CC(C)(C)F)c(F)c2)C(C)(C)C)cc1 |
| Storage condition | 2-8°C |