PROTAC ER Degrader-4

Modify Date: 2024-01-10 18:48:26

PROTAC ER Degrader-4 Structure
PROTAC ER Degrader-4 structure
Common Name PROTAC ER Degrader-4
CAS Number 2361114-15-8 Molecular Weight 1005.19
Density N/A Boiling Point N/A
Molecular Formula C53H67F3N6O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PROTAC ER Degrader-4


PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].

 Names

Name PROTAC ER Degrader-4

 PROTAC ER Degrader-4 Biological Activity

Description PROTAC ER Degrader-4 is a PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1].
Related Catalog
Target

VHL

ER

In Vitro PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].
References

[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.

 Chemical & Physical Properties

Molecular Formula C53H67F3N6O8S
Molecular Weight 1005.19
Storage condition 2-8°C
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