BSJ-03-123

Modify Date: 2024-01-10 16:53:45

BSJ-03-123 Structure
BSJ-03-123 structure
Common Name BSJ-03-123
CAS Number 2361493-16-3 Molecular Weight 937.008
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C48H57N9O11 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BSJ-03-123


BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.

 Names

Name N-[2-(2-{2-[2-(4-{6-[(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-1-piperazinyl)ethoxy]ethoxy}ethoxy)ethyl]-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
Synonym More Synonyms

 BSJ-03-123 Biological Activity

Description BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC) that uniquely enables rapid pharmacological interrogation of CDK6-dependent functions.
In Vitro BSJ-03-123 is a potent, CDK6-selective small-molecule degrader (PROTAC). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C48H57N9O11
Molecular Weight 937.008
Exact Mass 936.413025
LogP 0.28
Index of Refraction 1.628

 Synonyms

N-[2-(2-{2-[2-(4-{6-[(6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-1-piperazinyl)ethoxy]ethoxy}ethoxy)ethyl]-2-{[2-(2,6-dioxo-3-piperidinyl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
Acetamide, N-[2-[2-[2-[2-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
MFCD31813815
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