Urea,N-(2-chloroethyl)-N-nitroso

Modify Date: 2025-12-26 16:48:57

Urea,N-(2-chloroethyl)-N-nitroso Structure
Urea,N-(2-chloroethyl)-N-nitroso structure
Common Name Urea,N-(2-chloroethyl)-N-nitroso
CAS Number 2365-30-2 Molecular Weight 151.55200
Density 1.56g/cm3 Boiling Point 241.2ºC at 760mmHg
Molecular Formula C3H6ClN3O2 Melting Point N/A
MSDS N/A Flash Point 99.7ºC

 Names

Name 1-(2-chloroethyl)-1-nitrosourea
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.56g/cm3
Boiling Point 241.2ºC at 760mmHg
Molecular Formula C3H6ClN3O2
Molecular Weight 151.55200
Flash Point 99.7ºC
Exact Mass 151.01500
PSA 75.76000
LogP 0.98760
Vapour Pressure 0.0364mmHg at 25°C
Index of Refraction 1.566
InChIKey NVKGVBZZSJFQLM-UHFFFAOYSA-N
SMILES NC(=O)N(CCCl)N=O

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS5015000
CHEMICAL NAME :
Urea, 1-(2-chloroethyl)-1-nitroso-
CAS REGISTRY NUMBER :
2365-30-2
LAST UPDATED :
199612
DATA ITEMS CITED :
23
MOLECULAR FORMULA :
C3-H6-Cl-N3-O2
MOLECULAR WEIGHT :
151.57
WISWESSER LINE NOTATION :
ZVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4368 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD10 - Lethal Dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4700 ug/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
10 mmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,1887,1984

 Safety Information

HS Code 2924199090

 Synthetic Route

~%

Urea,N-(2-chloroethyl)-N-nitroso Structure

Urea,N-(2-chlor...

CAS#:2365-30-2

Literature: Lown; Chauhan Journal of Organic Chemistry, 1981 , vol. 46, # 26 p. 5309 - 5321

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Urea,N-(2-chloroethyl)-N-nitrosoBioassay

View more

Name: Antitumor activity against lymphoid leukemia L1210 cell implanted in mice was measure...
Source: ChEMBL
Target: L1210
External Id: CHEMBL702935
Name: Carbamoylating activity was determined
Source: ChEMBL
Target: N/A
External Id: CHEMBL626614
Name: Compound was evaluated for its ability to exhibit alkylating property toward DNA at 5...
Source: ChEMBL
Target: N/A
External Id: CHEMBL884891
Name: Tested for 3 log kill of leukemia cells
Source: ChEMBL
Target: L1210
External Id: CHEMBL731670
Name: Partition coefficient (logP)
Source: ChEMBL
Target: N/A
External Id: CHEMBL635482
Name: Percent ability of compound to produce DNA interstrand cross-links was determined by ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL845520
Name: Alkylating activity was determined
Source: ChEMBL
Target: N/A
External Id: CHEMBL630285
Name: Antitumor activity against lymphoid leukemia L1210 cell implanted in mice was measure...
Source: ChEMBL
Target: L1210
External Id: CHEMBL707842
Name: Toxicity against L-1210 leukemia cells in mice after intraperitoneal administration, ...
Source: ChEMBL
Target: L1210
External Id: CHEMBL737404
Name: Antitumor activity against lymphoid leukemia L1210 cell implanted in mice was measure...
Source: ChEMBL
Target: L1210
External Id: CHEMBL707119
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 Synonyms

N-Chloroethyl-N-nitrosourea
N-Nitroso-2-chloraethylharnstoff
2-Chloroethyl-N-nitrosourea
Chloroethylnitrosourea
MP 655
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