As-358 hydrochloride
Modify Date: 2025-08-27 12:19:40
As-358 hydrochloride structure
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Common Name | As-358 hydrochloride | ||
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| CAS Number | 2374723-26-7 | Molecular Weight | 329.91 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H32ClNO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of As-358 hydrochlorideAs-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1]. |
| Name | As-358 hydrochloride |
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| Description | As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1]. |
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| Related Catalog | |
| Target |
IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1] |
| In Vitro | As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV)[1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively. |
| In Vivo | As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1]. Animal Model: ICR mice[1] Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg Administration: IG; single (observed for 7 days) Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg. |
| References |
| Molecular Formula | C18H32ClNO2 |
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| Molecular Weight | 329.91 |