![]() Senexin C structure
|
Common Name | Senexin C | ||
---|---|---|---|---|
CAS Number | 2375554-02-0 | Molecular Weight | 449.558 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C28H27N5O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Senexin CSenexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability. |
Name | Senexin C |
---|
Description | Senexin C is a novel potent, selective and orally bioavailable CDK8/19 inhibitor with Kd of 1.4 and 2.9 nM for CDK8/CycC and CDK19/CycC, respectively.Senexin C inhibits CDK8/CycC with IC50 of 3.6 nM, shows high selectivity against other HDAC isoforms.Senexin C is more metabolically stable and provides a more sustained inhibition of CDK8/19-dependent cellular gene expression when compared with the prototype inhibitor Senexin B.Senexin C inhibits MV4-11 leukemia growth in a systemic in vivo model with good tolerability. |
---|---|
References | 1. Li Zhang, et al. J. Med. Chem. 2022 |
Molecular Formula | C28H27N5O |
---|---|
Molecular Weight | 449.558 |