Deferitrin
Modify Date: 2024-01-05 17:07:43
Deferitrin structure
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Common Name | Deferitrin | ||
|---|---|---|---|---|
| CAS Number | 239101-33-8 | Molecular Weight | 253.274 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 525.8±60.0 °C at 760 mmHg | |
| Molecular Formula | C11H11NO4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 271.8±32.9 °C | |
Use of DeferitrinDeferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2]. |
| Name | (2Z,4S)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)-4-methyl-1,3-thiazolidine-4-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 µmol/kg is shown to be 1.1%[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 525.8±60.0 °C at 760 mmHg |
| Molecular Formula | C11H11NO4S |
| Molecular Weight | 253.274 |
| Flash Point | 271.8±32.9 °C |
| Exact Mass | 253.040878 |
| PSA | 115.42000 |
| LogP | -0.13 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.683 |
|
~%
Deferitrin CAS#:239101-33-8 |
| Literature: Bergeron, Raymond J.; Wiegand, Jan; McManis, James S.; McCosar, Bruce H.; Weimar, William R.; Brittenham, Gary M.; Smith, Richard E. Journal of Medicinal Chemistry, 1999 , vol. 42, # 13 p. 2432 - 2440 |
|
~15%
Deferitrin CAS#:239101-33-8 |
| Literature: Genzyme Corporation Patent: US2003/220504 A1, 2003 ; Location in patent: Page/Page column 3-4 ; |
| (4S)-2-(2,4-Dihydroxyphenyl)-4-methyl-4,5-dihydro-1,3-thiazole-4-carboxylic acid |
| 4'-Hydroxydesazadesferrithiocin |
| GT 56-252 |
| 4-Thiazolecarboxylic acid, 2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-methyl-, (4S)- |
| UNII-T69Y9LDN44 |
| Deferitrin |