LDC0496

Modify Date: 2024-01-22 11:24:18

LDC0496 structure	Common Name	LDC0496
	CAS Number	2411874-83-2	Molecular Weight	537.65
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₂H₃₅N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of LDC0496

LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].

Name	LDC0496

Description	LDC0496 is a potent and selective EGFR inhibitor. LDC0496 possesses intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations, as well as selectivity over wild type EGFR and within the kinome[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	IC50: 0.152 ± 0.011 μM in Ba/F3 (EGFR-insNPH), 0.162 ± 0.010 μM in Ba/F3 (Her2-insYVMA), 2.660 ± 0.129 in A431[1]
References	[1]. Lategahn J, et al. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J Med Chem. 2022;65(9):6643-6655.

Molecular Formula	C₃₂H₃₅N₅O₃
Molecular Weight	537.65