PROTAC RAF degrader 1

Modify Date: 2024-01-27 11:20:24

PROTAC RAF degrader 1 structure	Common Name	PROTAC RAF degrader 1
	CAS Number	2413035-41-1	Molecular Weight	1010.18
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₁H₅₇F₂N₉O₇S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PROTAC RAF degrader 1

PROTAC RAF degrader 1 (compound 512) is a PROTAC RAF degrader. PROTAC RAF degrader 1 induces targeted degradation of BRAF mutants (DC50: 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). PROTAC RAF degrader 1 has anti-tumor activity. PROTAC RAF degrader 1 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF[1].

Name	PROTAC RAF degrader 1

Description	PROTAC RAF degrader 1 (compound 512) is a PROTAC RAF degrader. PROTAC RAF degrader 1 induces targeted degradation of BRAF mutants (DC50: 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). PROTAC RAF degrader 1 has anti-tumor activity. PROTAC RAF degrader 1 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf Signaling Pathways >> PROTAC >> PROTAC
References	[1]. Andrew P. Crew, et al. Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides. Patent. US 20200129627 A1.

Molecular Formula	C₅₁H₅₇F₂N₉O₇S₂
Molecular Weight	1010.18

PROTAC RAF degrader 1

Use of PROTAC RAF degrader 1

Names

PROTAC RAF degrader 1 Biological Activity

Chemical & Physical Properties